Ranker published an article about the Biosphere 2 project which was deemed a failure. When I visited the Biosphere when I was kid it was the coolest thing to imagine a building like that allowing us to colonize another planet. What I did not understand at the time was all the weirdness that it was involved. Mainly, because of the cult leader that had spear headed the whole project. Maybe had there been more science done in the actual program it may have been a success. The only good thing that came out of the original project was an intriguing answer to dying coral reefs.
Now, NASA is trying the same kind of program but on a smaller scale to get people ready to go to Mars. NASA is still in early stages of studying long term effects on humans in isolation but hopefully it gets better results.